[IEEE-bhpjobs] Fw: "Gene Delivery Approaches for Alzheimer Disease:Vectors and Transgenes"

[Esther Lumsdon]

-----Forwarded Message-----
From: AIATriangle at aol.com
Sent: Jan 25, 2005 11:52 AM
To: ProfLink at aol.com
Subject: "Gene Delivery Approaches for Alzheimer Disease:Vectors and Transgenes"


-----------------------------------------------------------------------------------------------------------------------

The NC Pharmaceutical Discussion Group Presents:
�
Dr. Jeffrey Hughes, Ph.D.

College of Pharmacy

University of Florida


"Gene Delivery Approaches for Alzheimer Disease:Vectors and Transgenes"


������������������������� Monday,�February 7th, 2005, 6 pm
�������������
�������������Sheraton Imperial Hotel and Convention Center
�������������Research Triangle Park
�������������4700 Emperor Blvd, Durham NC 27703
�������������1-919-941-5050

�

6:00 PM Cash Bar (one beverage included with dinner)
6:30 PM� Dinner
Seminar following Dinner
Cost: $50 if paid by February 1
Otherwise, $55
$10 for university students and� faculty
Note: Pre-registration and prepayment are greatly encouraged.� The people who 
walk in�may receive an alternate meal.

�
Please RSVP to ybutler at PharmaDirections.com�to register for this event (the 
registration form is attached).
�
Abstract
The seminar will discuss recent developments in gene transfer procedures for 
the therapy/prevention of Alzheimer?s disease (AD).� The underlying premise is 
that gene transfer offers a unique manner to impact� different aspects of the 
pathology of AD.� The therapeutic potential of gene transfer for neurological 
disease is promising, yet their remains substantial technical and theoretical 
problems to be solved before this technology can seriously be considered for 
clinical application.� In this presentation, efficient plasmid based gene 
transfer systems will be discussed. Plasmid based gene delivery vectors are 
attractive because these vectors avoid potential problems associated with the use of 
viruses.�� Data will be presented for a plasmid coding for the human protein 
gelsolin, given by the hydrodynamic gene administration for localized 
expression into the liver.�� Gelsolin is one of a class of proteins known as amyloid 
peptide binding agents.� These proteins can reversibly bind with beta amyloid 
fragments and serve as a peripheral sink thus increasing the clearance of 
amyloid fragments from the brain and should result in decrease amyloid deposition 
and cellular damage.� An alternative system will also be addressed for the 
expression of nerve growth factor within the brain for neuroprotection.� The 
presentation will focus on formulation and delivery aspects of successful plasmid 
DNA and expression in tissue culture models and animal models of Alzheimer ?s 
disease.

Bio:

Jeff Hughes�has a Bachelor's and PharmD�degree in Pharmacy�and a PhD 
in�Pharmaceutics from the University of Kentucky.� He is currently Associate Professor 
in the College of Pharmacy at the University of Florida where he has spent 
the last 10 years.� Prior to this position, he completed a post-doctoral 
fellowship�at the University of North Carolina, Department of Pharmacology.� He has 
served on the editorial board for several pharmaceutical 
publications.��His�research includes:�developing new delivery systems for the delivery of drugs to 
macrophages in the lung as treatment for tuberculosis, developing new therapies 
and models for Alzheimer's Disease, characterizing AAV-2 expression systems 
in the brain, and investigation of antimicrobial aspects of defensins.� 



Esther L., esther_L at ieee.org   
sending via webmail; please reply to esther_L at ieee.org\r\n
-------------- next part --------------
A non-text attachment was scrubbed...
Name: NCPDGRegistrationFeb-7-04.doc
Type: application/octet-stream
Size: 30208 bytes
Desc: not available
Url : http://rtpnet.org/pipermail/ieee-bhpjobs/attachments/20050125/a9e3ce66/NCPDGRegistrationFeb-7-04-0001.obj