[IEEE-bhpjobs] correction 29 April
Walter Heger
heger_walter at hotmail.com
Fri Apr 29 10:12:31 EDT 2005
Sorry, it is today, check the calender
http://vis.duke.edu/FridayForum/05Spring.html
Visualization Friday Forum
Friday, April 29nd noon-1pm in room D106 LSRC
Duke University, park by the tower on West campus,
or at the Duke Washington Golf course and take the bus.
Lunch will be served
Protein Protein Interfaces
Speaker: Johannes Rudolph, Department of Biochemistry
Protein-protein interactions form the basis for most cellular
processes,
including events intimately linked to human diseases. Despite their
importance, our understanding of the molecular details of
protein-protein
interactions remains poor, lagging far behind that of protein folding
and
structure. Descriptors and visual tools that describe protein
interfaces
are needed to discover the universal rules expected to govern the
specificity and efficiency of protein-protein association. Recently,
we
have used tools from computational geometry to define a protein
interface
surface. We can define a hierarchy of structures on this interface
surface.
Primary structure describes adjacencies, either on one side of the
interface
or across the interface. Secondary structure describes small recurring
geometric motifs. Tertiary structure describes the landscape of these
motifs. Here we describe the visualization of these primary and
secondary
structures of protein interfaces.
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