[IEEE-bhpjobs] Monday Mar 6th, 11am, Schiciano Auditorium B, Fitzpatrick Center

[Walter Heger]

Fritz Roth is speaking in the comp bio seminar series next Mon Mar 6th
at 11 and will be around all day, including dinner. Please get
in touch with Shandra Robertson <shandra.robertson at duke.edu> who is
organising his schedule in case you have time and are interested in
meeting with
him!

Below is the abstract
-- Uwe

------------------------------------

Computational Biology Seminar Series
Monday Mar 6th, 11am, Schiciano Auditorium B, Fitzpatrick Center
(FCIEMAS)

Frederick Roth, Harvard Medical School

Network analysis of genetic interaction in S. cerevisiae

Two genes have a synthetic lethal interaction if mutations in each
gene separately are tolerable, but simultaneous mutation in both genes
causes cell death. Such interactions provide robustness of an organism
to mutation. We examined synthetic sick or lethal (SSL) genetic
interactions from a systematic assay of over 700,000 gene pairs in S.
cerevisiae, assessing the value of SSL and protein interactions in
predicting gene function; relationships to other biological networks;
and the role of transcriptional compensation in robustness to gene
loss.  We have also examined more complex genetic interactions amongst
a
smaller set of genes providing resistance to the DNA damaging agent
methyl methanesulfonate.  We classified genetic interactions into
multiple types and developed algorithms to characterize order of action
in DNA repair pathways.

____________________________________________________
Frederick P. "Fritz" Roth, Asst. Professor,
Harvard Medical School / BCMP Dept.
250 Longwood Avenue, SGMB-322, Boston, MA 02115
phone:(617) 432-3551  fritz_roth @hms.harvard.edu
fax:  (617) 432-3557   http://llama.med.harvard.edu
____________________________________________________


--
Uwe Ohler                  | Assistant Professor, Computational Biology
email: uwe.ohler at duke.edu  | Institute for Genome Sciences and Policy
phone: (919) 668-5388      | CIEMAS Bldg, 101 Science Dr, Box 3382
fax:   (919) 668-0795      | Duke University
http://www.genome.duke.edu | Durham, NC 27708

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